Well…if what the article @lukeiamyourfather posted is more true than not, and one believes that once one big-tech, privacy-murdering, nanny-state-supporting software company starts doing this they all eventually will, I’d say it has effectively become impossible to make Win10 secure in the way Qubes is talking about.
But, “secure” issue aside, just being able to decide what your OS will and won’t do, and when, is a huge bonus, IMO.
Mostly to check to see if it is compatible with my current hardware, I guess. I’ll look more closely at web-site to see if they have a tool or something that examines a particular configuration and says “OK” or “nope”.